Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin

Vascular endothelial (VE)–protein tyrosine phosphatase (PTP) associates with VE-cadherin, thereby supporting its adhesive activity and endothelial junction integrity. VE-PTP also associates with Tie-2, dampening the tyrosine kinase activity of this receptor that can support stabilization of endothel...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Frye, Maike, Dierkes, Martina, Küppers, Verena, Vockel, Matthias, Tomm, Janina, Zeuschner, Dagmar, Rossaint, Jan, Zarbock, Alexander, Koh, Gou Young, Peters, Kevin, Nottebaum, Astrid Fee, Vestweber, Dietmar
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689167/
https://ncbi.nlm.nih.gov/pubmed/26642851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150718
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