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Pharmacokinetics of Alemtuzumab in Pediatric Patients Undergoing ex vivo T-Cell Depleted Haploidentical Hematopoietic Cell Transplantation

PURPOSE: Alemtuzumab is a humanized monoclonal antibody against CD52 which is predominantly present on T- and B-lymphocytes. Alemtuzumab has been used as part of conditioning regimens for prophylaxis against rejection and GVHD. While the mechanism of action is well-understood, the pharmacokinetics o...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Bhoopalan, Senthil Velan, Cross, Shane J., Panetta, John C., Triplett, Brandon M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735192/
https://ncbi.nlm.nih.gov/pubmed/33037919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-020-04160-7
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