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Enhancer-gene rewiring in the pathogenesis of Quebec platelet disorder
Quebec platelet disorder (QPD) is an autosomal dominant bleeding disorder with a unique, platelet-dependent, gain-of-function defect in fibrinolysis, without systemic fibrinolysis. The hallmark feature of QPD is a >100-fold overexpression of PLAU, specifically in megakaryocytes. This overexpressi...
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| 出版年: | Blood |
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| 主要な著者: | , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2020
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7735161/ https://ncbi.nlm.nih.gov/pubmed/32663239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005394 |
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