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ELABELA ameliorates hypoxic/ischemic-induced bone mesenchymal stem cell apoptosis via alleviation of mitochondrial dysfunction and activation of PI3K/AKT and ERK1/2 pathways

BACKGROUND: Mesenchymal stem cells (MSCs) have exerted their brilliant potential to promote heart repair following myocardial infarction. However, low survival rate of MSCs after transplantation due to harsh conditions with hypoxic and ischemic stress limits their therapeutic efficiency in treating...

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Publicat a:Stem Cell Res Ther
Autors principals: Fu, Jiaying, Chen, Xuxiang, Liu, Xin, Xu, Daishi, Yang, Huan, Zeng, Chaotao, Long, Huibao, Zhou, Changqing, Wu, Haidong, Zheng, Guanghui, Wu, Hao, Wang, Wuming, Wang, Tong
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734864/
https://ncbi.nlm.nih.gov/pubmed/33317626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-02063-1
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