Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833

[Image: see text] Herein we describe our efforts using a late stage functionalization together with more traditional synthetic approaches to generate fluorinated analogues of the clinical candidate AZD9833. The effects of the addition of fluorine on the lipophilicity, permeability, and metabolism ar...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Scott, James S., Moss, Thomas A., Barlaam, Bernard, Davey, Paul R. J., Fairley, Gary, Gangl, Eric T., Greenwood, Ryan D. R., Hatoum-Mokdad, Holia, Lister, Andrew S., Longmire, David, Polanski, Radoslaw, Stokes, Stephen, Tucker, Michael J., Varnes, Jeffrey G., Yang, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734794/
https://ncbi.nlm.nih.gov/pubmed/33335676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00505
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