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Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands

[Image: see text] Osimertinib is a third-generation tyrosine kinase inhibitor (TKI) and currently the gold-standard for the treatment of patients suffering from non-small cell lung cancer (NSCLC) harboring T790M-mutated epidermal growth factor receptor (EGFR). The outcome of the treatment, however,...

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: Niggenaber, Janina, Heyden, Leonie, Grabe, Tobias, Müller, Matthias P., Lategahn, Jonas, Rauh, Daniel
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2020
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734789/
https://ncbi.nlm.nih.gov/pubmed/33335671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00472
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