Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells

The brain is composed of cells having distinct genomic DNA sequences that arise post-zygotically, known as somatic genomic mosaicism (SGM). One form of SGM is aneuploidy—the gain and/or loss of chromosomes—which is associated with mitotic spindle defects. The mitotic spindle orientation determines c...

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Vydáno v:Mol Brain
Hlavní autoři: McDonald, Whitney S., Miyamoto, Kyoko, Rivera, Richard, Kennedy, Grace, Almeida, Beatriz S. V., Kingsbury, Marcy A., Chun, Jerold
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734743/
https://ncbi.nlm.nih.gov/pubmed/33317583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-020-00709-y
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