Stabilization Strategies for Linear Minigastrin Analogues: Further Improvements via the Inclusion of Proline into the Peptide Sequence

[Image: see text] Minigastrin (MG) analogues, known for their high potential to target cholecystokinin-2 receptor (CCK2R) expressing tumors, have limited clinical applicability due to low enzymatic stability. By introducing site-specific substitutions within the C-terminal receptor-binding sequence,...

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Udgivet i:J Med Chem
Main Authors: Klingler, Maximilian, Hörmann, Anton A., Rangger, Christine, Desrues, Laurence, Castel, Hélène, Gandolfo, Pierrick, von Guggenberg, Elisabeth
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734625/
https://ncbi.nlm.nih.gov/pubmed/33226806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01233
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