Intravenous alteplase for unknown time of onset stroke guided by advanced imaging: a systematic review and meta-analysis of individual patient data

BACKGROUND –: Stroke patients with unknown time of onset have been previously excluded from thrombolysis. We aimed to determine whether intravenous alteplase is safe and effective in these patients when salvageable tissue is identified using imaging biomarkers. METHODS –: We performed a systematic r...

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Publicado no:Lancet
Main Authors: Thomalla, Götz, Boutitie, Florent, Ma, Henry, Koga, Masatoshi, Ringleb, Peter, Schwamm, Lee H., Wu, Ona, Bendszus, Martin, Bladin, Christopher F, Campbell, Bruce C.V., Cheng, Bastian, Churilov, Leonid, Ebinger, Martin, Endres, Matthias, Fiebach, Jochen B., Fukuda-Doi, Mayumi, Inoue, Manabu, Kleinig, Timothy J., Latour, Lawrence L., Lemmens, Robin, Levi, Christopher R, Leys, Didier, Miwa, Kaori, Molina, Carlos A., Muir, Keith W., Nighoghossian, Norbert, Parsons, Mark W., Pedraza, Salvador, Schellinger, Peter D., Schwab, Stefan, Simonsen, Claus Z., Song, Shlee S., Thijs, Vincent, Toni, Danilo, Hsu, Chung Y., Wahlgren, Nils, Yamamoto, Haruko, Yassi, Nawaf, Yoshimura, Sohei, Warach, Steven, Hacke, Werner, Toyoda, Kazunori, Donnan, Geoffrey A., Davis, Stephen M., Gerloff, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734592/
https://ncbi.nlm.nih.gov/pubmed/33176180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(20)32163-2
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