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Design of a multivalent bifunctional chelator for diagnostic (64)Cu PET imaging in Alzheimer’s disease
Herein, we report a (64)Cu positron emission tomography (PET) imaging agent that shows appreciable in vivo brain uptake and exhibits high specific affinity for beta-amyloid (Aβ) aggregates, leading to the successful PET imaging of amyloid plaques in the brains of 5xFAD mice versus those of wild-type...
Gardado en:
| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7733815/ https://ncbi.nlm.nih.gov/pubmed/33234563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014058117 |
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