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Deep learning and generative methods in cheminformatics and chemical biology: navigating small molecule space intelligently

The number of ‘small’ molecules that may be of interest to chemical biologists — chemical space — is enormous, but the fraction that have ever been made is tiny. Most strategies are discriminative, i.e. have involved ‘forward’ problems (have molecule, establish properties). However, we normally wish...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Kell, Douglas B., Samanta, Soumitra, Swainston, Neil
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733676/
https://ncbi.nlm.nih.gov/pubmed/33290527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200781
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