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Label-free vibrational imaging of different Aβ plaque types in Alzheimer’s disease reveals sequential events in plaque development

The neuropathology of Alzheimer’s disease (AD) is characterized by hyperphosphorylated tau neurofibrillary tangles (NFTs) and amyloid-beta (Aβ) plaques. Aβ plaques are hypothesized to follow a development sequence starting with diffuse plaques, which evolve into more compact plaques and finally matu...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Röhr, Dominik, Boon, Baayla D. C., Schuler, Martin, Kremer, Kristin, Hoozemans, Jeroen J. M., Bouwman, Femke H., El-Mashtoly, Samir F., Nabers, Andreas, Großerueschkamp, Frederik, Rozemuller, Annemieke J. M., Gerwert, Klaus
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733282/
https://ncbi.nlm.nih.gov/pubmed/33308303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01091-5
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