GDF11 contributes to hepatic HAMP inhibition through SMURF1-mediated BMP-SMAD signalling suppression

Hepcidin (HAMP) synthesis is suppressed by erythropoiesis to increase iron availability for red blood cell production. This effect is thought to result from factors secreted by erythroid precursors. Growth differentiation factor 11 (GDF11) expression was recently shown to increase in erythroid cells...

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Udgivet i:Br J Haematol
Main Authors: Fang, Zheng, Zhu, Zesen, Zhang, Haihang, Peng, Yuanliang, Liu, Jin, Lu, Hongyu, Li, Jiang, Liang, Long, Xia, Shenghua, Wang, Qiguang, Fu, Bin, Wu, Kunlu, Zhang, Lingqiang, Ginzburg, Yelena, Liu, Jing, Chen, Huiyong
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733280/
https://ncbi.nlm.nih.gov/pubmed/31418854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.16156
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