Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response

HIF-1-mediated adaptation to changes in oxygen availability is a critical aspect of healthy physiology. HIF is regulated by a conserved mechanism whereby EGLN/PHD family members hydroxylate HIF in an oxygen-dependent manner, targeting it for ubiquitination by Von-Hippel-Lindau (VHL) family members,...

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Publicado en:GeroScience
Main Authors: Kruempel, Joseph C.P., Miller, Hillary A., Schaller, Megan L., Fretz, Abrielle, Howington, Marshall, Sarker, Marjana, Huang, Shijiao, Leiser, Scott F.
Formato: Artigo
Idioma:Inglês
Publicado: Springer International Publishing 2020
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732922/
https://ncbi.nlm.nih.gov/pubmed/32399915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00194-0
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