Induction of HO-1 by 5, 8-Dihydroxy-4′,7-Dimethoxyflavone via Activation of ROS/p38 MAPK/Nrf2 Attenuates Thrombin-Induced Connective Tissue Growth Factor Expression in Human Cardiac Fibroblasts

Heme oxygenase-1 (HO-1) has been shown to exert as an antioxidant and anti-inflammatory enzyme in cardiovascular inflammatory diseases. Flavonoids have been demonstrated to display anti-inflammatory and antioxidant effects through the induction of HO-1. 5,8-Dihydroxy-4′,7-dimethoxyflavone (DDF), one...

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Dades bibliogràfiques
Publicat a:Oxid Med Cell Longev
Autors principals: Yang, Chien-Chung, Hsiao, Li-Der, Lin, Hsin-Hui, Tseng, Hui-Ching, Situmorang, Jiro Hasegawa, Leu, Yann-Lii, Yang, Chuen-Mao
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732388/
https://ncbi.nlm.nih.gov/pubmed/33343802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/1080168
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