Quantification of Temozolomide in Nonhuman Primate Fluids by Isocratic Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry to Study Brain Tissue Penetration Following Intranasal or Intravenous Delivery

A sensitive and selective ultra-high performance liquid chromatography-tandem mass spectrometric method was developed for the quantification of temozolomide (TMZ) in nonhuman primate (NHP) plasma, cerebrospinal fluid (CSF), and brain extracellular fluid (ECF) following microdialysis. Ethyl acetate w...

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Vydáno v:Separations
Hlavní autoři: Peer, Cody J., Ronner, Lukas, Rodgers, Louis, Lester McCully, Cynthia M., Warren, Katherine E., Figg, William D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7731907/
https://ncbi.nlm.nih.gov/pubmed/33313078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/chromatography3010004
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