VWF maturation and release are controlled by 2 regulators of Weibel-Palade body biogenesis: exocyst and BLOC-2

von Willebrand factor (VWF) is an essential hemostatic protein that is synthesized in endothelial cells and stored in Weibel-Palade bodies (WPBs). Understanding the mechanisms underlying WPB biogenesis and exocytosis could enable therapeutic modulation of endogenous VWF, yet optimal targets for modu...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Sharda, Anish V., Barr, Alexandra M., Harrison, Joshua A., Wilkie, Adrian R., Fang, Chao, Mendez, Lourdes M., Ghiran, Ionita C., Italiano, Joseph E., Flaumenhaft, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7731791/
https://ncbi.nlm.nih.gov/pubmed/32614949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005300
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