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Cell-autonomous role of Presenilin in age-dependent survival of cortical interneurons
BACKGROUND: Mutations in the PSEN1 and PSEN2 genes are the major cause of familial Alzheimer’s disease. Previous studies demonstrated that Presenilin (PS), the catalytic subunit of γ-secretase, is required for survival of excitatory neurons in the cerebral cortex during aging. However, the role of P...
Gespeichert in:
| Veröffentlicht in: | Mol Neurodegener |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7731773/ https://ncbi.nlm.nih.gov/pubmed/33302995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00419-y |
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