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An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain

Mutations in the Presenilin genes are the major genetic cause of Alzheimer’s disease. Presenilin and Nicastrin are essential components of γ-secretase, a multi-subunit protease that cleaves Type I transmembrane proteins. Genetic studies in mice previously demonstrated that conditional inactivation o...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Kang, Jongkyun, Shin, Sarah, Perrimon, Norbert, Shen, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500145/
https://ncbi.nlm.nih.gov/pubmed/28495961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.196881
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