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An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain
Mutations in the Presenilin genes are the major genetic cause of Alzheimer’s disease. Presenilin and Nicastrin are essential components of γ-secretase, a multi-subunit protease that cleaves Type I transmembrane proteins. Genetic studies in mice previously demonstrated that conditional inactivation o...
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| Publicado no: | Genetics |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5500145/ https://ncbi.nlm.nih.gov/pubmed/28495961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.196881 |
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