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An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain

Mutations in the Presenilin genes are the major genetic cause of Alzheimer’s disease. Presenilin and Nicastrin are essential components of γ-secretase, a multi-subunit protease that cleaves Type I transmembrane proteins. Genetic studies in mice previously demonstrated that conditional inactivation o...

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Vydáno v:Genetics
Hlavní autoři: Kang, Jongkyun, Shin, Sarah, Perrimon, Norbert, Shen, Jie
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500145/
https://ncbi.nlm.nih.gov/pubmed/28495961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.196881
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