Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation

In human lupus nephritis, tubulointerstitial inflammation (TII) is associated with in situ expansion of B cells expressing anti-vimentin antibodies (AVAs). The mechanism by which AVAs are selected is unclear. Herein, we demonstrate that AVA somatic hypermutation (SHM) and selection increase affinity...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kinloch, Andrew J., Asano, Yuta, Mohsin, Azam, Henry, Carole, Abraham, Rebecca, Chang, Anthony, Labno, Christine, Wilson, Patrick C., Clark, Marcus R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7731665/
https://ncbi.nlm.nih.gov/pubmed/33329582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.593177
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