Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation

In human lupus nephritis, tubulointerstitial inflammation (TII) is associated with in situ expansion of B cells expressing anti-vimentin antibodies (AVAs). The mechanism by which AVAs are selected is unclear. Herein, we demonstrate that AVA somatic hypermutation (SHM) and selection increase affinity...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Kinloch, Andrew J., Asano, Yuta, Mohsin, Azam, Henry, Carole, Abraham, Rebecca, Chang, Anthony, Labno, Christine, Wilson, Patrick C., Clark, Marcus R.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7731665/
https://ncbi.nlm.nih.gov/pubmed/33329582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.593177
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars