Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis

OBJECTIVE: In lupus nephritis (LuN), severe tubulointerstitial inflammation (TII) predicts progression to renal failure. Severe TII is associated with tertiary lymphoid neogenesis and in situ antigen-driven clonal B cell selection. The autoantigen(s) driving in situ B-cell selection in TII are not k...

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Published in:Arthritis Rheumatol
Main Authors: Kinloch, Andrew J, Chang, Anthony, Ko, Kichul, Dunand, Carole J Henry, Henderson, Scott, Maienschein-Cleine, Mark, Kaverina, Natalya, Rovin, Brad, Ferrer, Marlene Salgado, Wolfgeher, Don, Liarski, Vladimir, Haddon, D James, Utz, Paul J, Wilson, Patrick C, Clark, Marcus R
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264660/
https://ncbi.nlm.nih.gov/pubmed/25306868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38888
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