Tropinone-Derived Alkaloids as Potent Anticancer Agents: Synthesis, Tyrosinase Inhibition, Mechanism of Action, DFT Calculation, and Molecular Docking Studies

A new series of hybrid compounds with tropinone and thiazole rings in the structure was designed and synthesized as potential anticancer agents. They were tested against human multiple myeloma (RPMI 8226), lung carcinoma (A549), breast adenocarcinoma (MDA-MB-231), and mouse skin melanoma (B16-F10) c...

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Publicado en:Int J Mol Sci
Autores principales: Piechowska, Katarzyna, Mizerska-Kowalska, Magdalena, Zdzisińska, Barbara, Cytarska, Joanna, Baranowska-Łączkowska, Angelika, Jaroch, Karol, Łuczykowski, Kamil, Płaziński, Wojciech, Bojko, Barbara, Kruszewski, Stefan, Misiura, Konrad, Łączkowski, Krzysztof Z.
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7731314/
https://ncbi.nlm.nih.gov/pubmed/33260768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239050
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