Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro

The cytokine interleukin-6 (IL-6) fulfills its pleiotropic functions via different modes of signaling. Regenerative and anti-inflammatory activities are mediated via classic signaling, in which IL-6 binds to the membrane-bound IL-6 receptor (IL-6R). For IL-6 trans-signaling, which accounts for the p...

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Publicat a:Sci Rep
Autors principals: Flynn, Charlotte M., Garbers, Yvonne, Düsterhöft, Stefan, Wichert, Rielana, Lokau, Juliane, Lehmann, Christian H. K., Dudziak, Diana, Schröder, Bernd, Becker-Pauly, Christoph, Rose-John, Stefan, Aparicio-Siegmund, Samadhi, Garbers, Christoph
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730449/
https://ncbi.nlm.nih.gov/pubmed/33303781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77884-4
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