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Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1α-NF-κB Crosstalk In Vitro and In Vivo

Phorbol 12-myristate 13-acetate (PMA) is a potent tumor promoter and highly inflammatory in nature. Here, we investigated the toxic effects of PMA on different model system. PMA (10 μg) caused chromosomal aberrations on the Allium cepa root tip and induced mitotic dysfunction. Similarly, PMA caused...

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書誌詳細
出版年:Int J Mol Sci
主要な著者: Chang, Sukkum Ngullie, Dey, Debasish Kumar, Oh, Seong Taek, Kong, Won Ho, Cho, Kiu Hyung, Al-Olayan, Ebtesam M., Hwang, Buyng Su, Kang, Sun Chul, Park, Jae Gyu
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7729754/
https://ncbi.nlm.nih.gov/pubmed/33291656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239261
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