Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1α-NF-κB Crosstalk In Vitro and In Vivo

Phorbol 12-myristate 13-acetate (PMA) is a potent tumor promoter and highly inflammatory in nature. Here, we investigated the toxic effects of PMA on different model system. PMA (10 μg) caused chromosomal aberrations on the Allium cepa root tip and induced mitotic dysfunction. Similarly, PMA caused...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Chang, Sukkum Ngullie, Dey, Debasish Kumar, Oh, Seong Taek, Kong, Won Ho, Cho, Kiu Hyung, Al-Olayan, Ebtesam M., Hwang, Buyng Su, Kang, Sun Chul, Park, Jae Gyu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7729754/
https://ncbi.nlm.nih.gov/pubmed/33291656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239261
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