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Design, Synthesis, and Molecular Docking of Paracyclophanyl-Thiazole Hybrids as Novel CDK1 Inhibitors and Apoptosis Inducing Anti-Melanoma Agents

Three new series of paracyclophanyl-dihydronaphtho[2,3-d]thiazoles and paracyclophanyl-thiazolium bromides were designed, synthesized, and characterized by their spectroscopic data, along with X-ray analysis. One-dose assay results of anticancer activity indicated that 3a–e had the highest ability t...

詳細記述

保存先:
書誌詳細
出版年:Molecules
主要な著者: Aly, Ashraf A., Bräse, Stefan, Hassan, Alaa A., Mohamed, Nasr K., El-Haleem, Lamiaa E. Abd, Nieger, Martin, Morsy, Nesrin M., Alshammari, Mohammed B., Ibrahim, Mahmoud A. A., Abdelhafez, Elshimaa M. N.
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7729638/
https://ncbi.nlm.nih.gov/pubmed/33260954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25235569
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