Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells

Most breast cancers exhibit low immune infiltration and are unresponsive to immunotherapy. We hypothesized that inhibition of the receptor activator of nuclear factor-κB (RANK) signaling pathway may enhance immune activation. Here we report that loss of RANK signaling in mouse tumor cells increases...

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Publié dans:Nat Commun
Auteurs principaux: Gómez-Aleza, Clara, Nguyen, Bastien, Yoldi, Guillermo, Ciscar, Marina, Barranco, Alexandra, Hernández-Jiménez, Enrique, Maetens, Marion, Salgado, Roberto, Zafeiroglou, Maria, Pellegrini, Pasquale, Venet, David, Garaud, Soizic, Trinidad, Eva M., Benítez, Sandra, Vuylsteke, Peter, Polastro, Laura, Wildiers, Hans, Simon, Philippe, Lindeman, Geoffrey, Larsimont, Denis, Van den Eynden, Gert, Velghe, Chloé, Rothé, Françoise, Willard-Gallo, Karen, Michiels, Stefan, Muñoz, Purificación, Walzer, Thierry, Planelles, Lourdes, Penninger, Josef, Azim, Hatem A., Loi, Sherene, Piccart, Martine, Sotiriou, Christos, González-Suárez, Eva
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728758/
https://ncbi.nlm.nih.gov/pubmed/33303745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20138-8
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