EHMT2 epigenetically suppresses Wnt signaling and is a potential target in embryonal rhabdomyosarcoma

Wnt signaling is downregulated in embryonal rhabdomyosarcoma (ERMS) and contributes to the block of differentiation. Epigenetic mechanisms leading to its suppression are unknown and could pave the way toward novel therapeutic modalities. We demonstrate that EHMT2 suppresses canonical Wnt signaling b...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Pal, Ananya, Leung, Jia Yu, Ang, Gareth Chin Khye, Rao, Vinay Kumar, Pignata, Luca, Lim, Huey Jin, Hebrard, Maxime, Chang, Kenneth TE, Lee, Victor KM, Guccione, Ernesto, Taneja, Reshma
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2020
Konular:
Chromosomes and Gene Expression
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728445/
https://ncbi.nlm.nih.gov/pubmed/33252038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57683
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