EHMT2 epigenetically suppresses Wnt signaling and is a potential target in embryonal rhabdomyosarcoma

Wnt signaling is downregulated in embryonal rhabdomyosarcoma (ERMS) and contributes to the block of differentiation. Epigenetic mechanisms leading to its suppression are unknown and could pave the way toward novel therapeutic modalities. We demonstrate that EHMT2 suppresses canonical Wnt signaling b...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Pal, Ananya, Leung, Jia Yu, Ang, Gareth Chin Khye, Rao, Vinay Kumar, Pignata, Luca, Lim, Huey Jin, Hebrard, Maxime, Chang, Kenneth TE, Lee, Victor KM, Guccione, Ernesto, Taneja, Reshma
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Assuntos:
Chromosomes and Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728445/
https://ncbi.nlm.nih.gov/pubmed/33252038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57683
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