In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells

We report a serum-free, 3D murine artificial thymic organoid (M-ATO) system that mimics normal murine thymopoiesis with the production of all T cell stages, from early thymic progenitors to functional single-positive (CD8SP and CD4SP) TCRαβ and TCRγδ cells. RNA sequencing aligns M-ATO-derived popula...

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發表在:Cell Rep
Main Authors: Montel-Hagen, Amélie, Sun, Victoria, Casero, David, Tsai, Steven, Zampieri, Alexandre, Jackson, Nicholas, Li, Suwen, Lopez, Shawn, Zhu, Yuhua, Chick, Brent, He, Chongbin, de Barros, Stéphanie C., Seet, Christopher S., Crooks, Gay M.
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7727762/
https://ncbi.nlm.nih.gov/pubmed/33113379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108320
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