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In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells
We report a serum-free, 3D murine artificial thymic organoid (M-ATO) system that mimics normal murine thymopoiesis with the production of all T cell stages, from early thymic progenitors to functional single-positive (CD8SP and CD4SP) TCRαβ and TCRγδ cells. RNA sequencing aligns M-ATO-derived popula...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7727762/ https://ncbi.nlm.nih.gov/pubmed/33113379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108320 |
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