Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype

BACKGROUND & AIMS: Eosinophilic esophagitis (EoE) is an antigen-mediated eosinophilic disease of the esophagus that involves fibroblast activation and progression to fibrostenosis. Cytokines produced by T-helper type 2 cells and transforming growth factor beta 1 (TGFβ1) contribute to the develop...

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Publicado no:Gastroenterology
Main Authors: Manresa, Mario C., Chiang, Austin W. T., Kurten, Richard C., Dohil, Ranjan, Brickner, Howard, Dohil, Lucas, Herro, Rana, Akuthota, Praveen, Lewis, Nathan E., Croft, Michael, Aceves, Seema S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726704/
https://ncbi.nlm.nih.gov/pubmed/32712105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.07.035
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