Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective following Ischemic Brain Injury

Expression of the 17β-estradiol (E2) synthesis enzyme aromatase is highly upregulated in astrocytes following brain injury. However, the precise role of astrocyte-derived E2 in the injured brain remains unclear. In the current study, we generated a glial fibrillary acidic protein (GFAP) promoter-dri...

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Vydáno v:J Neurosci
Hlavní autoři: Wang, Jing, Sareddy, Gangadhara R., Lu, Yujiao, Pratap, Uday P., Tang, Fulei, Greene, Karah M., Meyre, Pornjittra L., Tekmal, Rajeshwar R., Vadlamudi, Ratna K., Brann, Darrell W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726540/
https://ncbi.nlm.nih.gov/pubmed/33158962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0888-20.2020
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