Structural Features of Heparin and Its Interactions With Cellular Prion Protein Measured by Surface Plasmon Resonance

Self-propagating form of the prion protein (PrP(Sc)) causes many neurodegenerative diseases, such as Creutzfeldt-Jakob disease (CJD) and Gerstmann-Straussler-Scheinker syndrome (GSS). Heparin is a highly sulfated linear glycosaminoglycan (GAG) and is composed of alternating D-glucosamine and L-iduro...

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Veröffentlicht in:Front Mol Biosci
Hauptverfasser: Kim, So Young, Zhang, Fuming, Harris, David A., Linhardt, Robert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Molecular Biosciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726446/
https://ncbi.nlm.nih.gov/pubmed/33324681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.594497
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