PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor Activity in Neuroblastoma by Repressing Expression of MYCN or c-Myc

Neuroblastoma (NB) is one of the most common solid tumors in childhood. To date, targeting MYCN, a well-established driver gene in high-risk neuroblastoma, is still challenging. In recent years, inhibition of bromodomain and extra terminal (BET) proteins shows great potential in multiple of Myc-driv...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Li, Zhiheng, Lim, Su Lin, Tao, Yanfang, Li, Xiaolu, Xie, Yi, Yang, Chun, Zhang, Zimu, Jiang, You, Zhang, Xianbing, Cao, Xu, Wang, Hairong, Qian, Guanghui, Wu, Yi, Li, Mei, Fang, Fang, Liu, Ying, Fu, Mingcui, Ding, Xin, Zhu, Zhenghong, Lv, Haitao, Lu, Jun, Xiao, Sheng, Hu, Shaoyan, Pan, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726414/
https://ncbi.nlm.nih.gov/pubmed/33324552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.574525
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