ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin Secretion Process

ARHGAP21 is a RhoGAP protein implicated in the modulation of insulin secretion and energy metabolism. ARHGAP21 transient-inhibition increase glucose-stimulated insulin secretion (GSIS) in neonatal islets; however, ARHGAP21 heterozygote mice have a reduced insulin secretion. These discrepancies are n...

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Veröffentlicht in:Front Endocrinol (Lausanne)
Hauptverfasser: Ferreira, Sandra M., Costa-Júnior, José M., Kurauti, Mirian A., Leite, Nayara C., Ortis, Fernanda, Rezende, Luiz F., Barbosa, Helena C., Boschero, Antonio C., Santos, Gustavo J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Endocrinology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726208/
https://ncbi.nlm.nih.gov/pubmed/33324349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2020.599165
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