Differential Regulation of mTOR Complexes with miR-302a Attenuates Myocardial Reperfusion Injury in Diabetes

Persistent activation of mTOR (mammalian target of rapamycin) in diabetes increases the vulnerability of the heart to ischemia/reperfusion (I/R) injury. We show here that infusion of rapamycin (mTOR inhibitor) at reperfusion following ischemia reduced myocardial infarct size and apoptosis with resto...

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Publicado en:iScience
Autores principales: Samidurai, Arun, Ockaili, Ramzi, Cain, Chad, Roh, Sean K., Filippone, Scott M., Kraskauskas, Donatas, Kukreja, Rakesh C., Das, Anindita
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725936/
https://ncbi.nlm.nih.gov/pubmed/33319180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101863
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