Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

Heme biosynthesis and iron-sulfur cluster (ISC) biogenesis are two major mammalian metabolic pathways that require iron. It has long been known that these two pathways interconnect, but the previously described interactions do not fully explain why heme biosynthesis depends on intact ISC biogenesis....

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Bibliographic Details
Published in:Nat Commun
Main Authors: Liu, Gang, Sil, Debangsu, Maio, Nunziata, Tong, Wing-Hang, Bollinger, J. Martin, Krebs, Carsten, Rouault, Tracey Ann
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725820/
https://ncbi.nlm.nih.gov/pubmed/33298951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20145-9
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