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The Hippo pathway coactivator Yorkie can reprogram cell fates and create compartment-boundary–like interactions at clone margins

During development, tissue-specific patterns of gene expression are established by transcription factors and then stably maintained via epigenetic mechanisms. Cancer cells often express genes that are inappropriate for that tissue or developmental stage. Here, we show that high activity levels of Yk...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Bairzin, Joanna C. D., Emmons-Bell, Maya, Hariharan, Iswar K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725458/
https://ncbi.nlm.nih.gov/pubmed/33298454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe8159
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