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Opposing effects of cohesin and transcription on CTCF organization revealed by super-resolution imaging

CTCF and cohesin play critical roles in organizing mammalian genomes into topologically associating domains (TADs). Here, by combining genetic engineering with quantitative super-resolution Stimulated Emission Depletion (STED) microscopy, we demonstrate that in living cells CTCF forms clusters typic...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell
Egile Nagusiak: Gu, Bo, Comerci, Colin J., McCarthy, Dannielle G., Saurabh, Saumya, Moerner, W. E., Wysocka, Joanna
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725164/
https://ncbi.nlm.nih.gov/pubmed/33091336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.10.001
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