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Designing the Furin-Cleavable Linker in Recombinant Immunotoxins Based on Pseudomonas Exotoxin A

Recombinant immunotoxins (RITs) are fusion proteins that join antibodies to protein toxins for targeted cell killing. RITs armed with Pseudomonas exotoxin A (PE) are undergoing clinical trials for the treatment of cancer. The current design of PE-based RITs joins an antibody fragment to the catalyti...

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Bibliografiske detaljer
Udgivet i:Bioconjug Chem
Main Authors: Weldon, John E., Skarzynski, Martin, Therres, Jamy A., Ostovitz, Joshua R., Zhou, Hong, Kreitman, Robert J., Pastan, Ira
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7724502/
https://ncbi.nlm.nih.gov/pubmed/25997032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.5b00190
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