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Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation
The calcium release-activated calcium channel Orai regulates Ca(2+) entry into non-excitable cells and is required for proper immune function. While the channel typically opens following Ca(2+) release from the endoplasmic reticulum, certain pathologic mutations render the channel constitutively ope...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7723414/ https://ncbi.nlm.nih.gov/pubmed/33252040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62772 |
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