Novel genetic associations with interferon in systemic lupus erythematosus identified by replication and fine-mapping of trait-stratified genome-wide screen

BACKGROUND/PURPOSE: High serum interferon alpha (IFN-α) is an important heritable phenotype in systemic lupus erythematosus (SLE) which is involved in primary disease pathogenesis. High vs. low levels of IFN-α are associated with disease severity and account for some of the biological heterogeneity...

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Vydáno v:Cytokine
Hlavní autoři: Ghodke-Puranik, Yogita, Imgruet, Molly, Dorschner, Jessica M., Shrestha, Prakriti, McCoy, Kaci, Kelly, Jennifer A., Marion, Miranda, Guthridge, Joel M., Langefeld, Carl D., Harley, John B., James, Judith A., Sivils, Kathy L., Niewold, Timothy B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7723062/
https://ncbi.nlm.nih.gov/pubmed/30685201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2018.12.014
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