Efficient Chemoenzymatic Synthesis of N‐Glycans with a β1,4‐Galactosylated Bisecting GlcNAc Motif

In human serum immunoglobulin G (IgG), a rare modification of biantennary complex N‐glycans lead to a β1,4‐galactosylated bisecting GlcNAc branch. We found that the bisecting GlcNAc on a biantennary core‐fucosylated N‐glycan was enzymatically galactosylated under stringent reaction conditions. Furth...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Weiss, Michael, Ott, Dimitri, Karagiannis, Theodoros, Weishaupt, Markus, Niemietz, Mathäus, Eller, Steffen, Lott, Marie, Martínez‐Orts, Mónica, Canales, Ángeles, Razi, Nahid, Paulson, James C., Unverzagt, Carlo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7723014/
https://ncbi.nlm.nih.gov/pubmed/32597008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000268
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