Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

Mammalian cells exhibit remarkable diversity in cell size, but the factors that regulate establishment and maintenance of these sizes remain poorly understood. This is especially true for skeletal muscle, comprised of syncytial myofibers that each accrue hundreds of nuclei during development. Here,...

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Vydáno v:Nat Commun
Hlavní autoři: Cramer, Alyssa A. W., Prasad, Vikram, Eftestøl, Einar, Song, Taejeong, Hansson, Kenth-Arne, Dugdale, Hannah F., Sadayappan, Sakthivel, Ochala, Julien, Gundersen, Kristian, Millay, Douglas P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722938/
https://ncbi.nlm.nih.gov/pubmed/33293533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20058-7
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