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Chronic alcohol exposure reduces acetylated histones in the sleep-wake regulatory brain regions to cause insomnia during withdrawal.

BACKGROUND: Alcohol use disorder (AUD) develops after chronic and heavy use of alcohol. Insomnia, a hallmark of AUD, plays a crucial role in the development of AUD. However, the causal mechanisms are unknown. Since chronic alcohol reduces acetylated histones and disrupts the epigenome, we hypothesiz...

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Publicado en:Neuropharmacology
Main Authors: Sharma, Rishi, Sahota, Pradeep, Thakkar, Mahesh M.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722632/
https://ncbi.nlm.nih.gov/pubmed/32961200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2020.108332
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