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Protein kinase A inhibitor proteins (PKIs) divert GPCR-Gαs-cAMP signaling towards EPAC and ERK activation and are involved in tumor growth
The PKA-inhibitor (PKI) family members PKIα, PKIβ and PKIγ bind with high affinity to PKA and block its kinase activity, modulating the extent and duration of PKA-mediated signaling events. While PKA is a well-known regulator of physiological and oncogenic events, the role of PKI proteins in these p...
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| Veröffentlicht in: | FASEB J |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7722164/ https://ncbi.nlm.nih.gov/pubmed/32830375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202001515R |
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