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A transgene targeted to the zebrafish nkx2.4b locus drives specific GFP expression and disrupts thyroid development

BACKGROUND: With the goal of labeling and manipulating the zebrafish hypothalamus, we sought to target a gfp transgene to the expression domains of nkx2.4b, a gene expressed during hypothalamic and thyroid development. We combined TALENs mediated mutagenesis with a targeting construct to enable inse...

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Bibliografske podrobnosti
izdano v:Dev Dyn
Main Authors: Hutcheson, David A., Xie, Yuanyuan, Figueroa, Priscilla, Dorsky, Richard I.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722092/
https://ncbi.nlm.nih.gov/pubmed/32644242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.224
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