Metabolism and pharmacokinetics of a novel polyphenol fatty acid ester phloridzin docosahexaenoate in Balb/c female mice

Flavonoids are known to undergo phase II metabolism and produce metabolites with similar or stronger biological effects compared to the parent flavonoids. However, the limited cellular uptake and bioavailability restrict their clinical use. We synthesized phloridzin docosahexaenoate (PZ-DHA), a nove...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Fernando, Wasundara, Goralski, Kerry B., Hoskin, David W., Rupasinghe, H. P. Vasantha
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7721897/
https://ncbi.nlm.nih.gov/pubmed/33288802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78369-0
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