Met125 is essential for maintaining the structural integrity of calmodulin’s C-terminal domain

We have used NMR and circular dichroism spectroscopy to investigate the structural and dynamic effects of oxidation on calmodulin (CaM), using peroxide and the Met to Gln oximimetic mutations. CaM is a Ca(2+)-sensitive regulatory protein that interacts with numerous targets. Due to its high methioni...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Nelson, Sarah E. D., Weber, Daniel K., Rebbeck, Robyn T., Cornea, Razvan L., Veglia, Gianluigi, Thomas, David D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7721703/
https://ncbi.nlm.nih.gov/pubmed/33288831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78270-w
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