Effect of isoform-specific HIF-1α and HIF-2α antisense oligonucleotides on tumorigenesis, inflammation and fibrosis in a hepatocellular carcinoma mouse model

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. For advanced HCC, there is still an unmet need for more effective therapeutic strategies. HCC is typically associated with hypoxia and the hypoxia-inducible factor (HIF) regulatory pathway plays an importa...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Vanderborght, Bart, De Muynck, Kevin, Lefere, Sander, Geerts, Anja, Degroote, Helena, Verhelst, Xavier, Van Vlierberghe, Hans, Devisscher, Lindsey
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7721613/
https://ncbi.nlm.nih.gov/pubmed/33400730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27830
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